Denis L.J. Lafontaine received a research MSc (1991) and a PhD (1995) in Molecular Biology & Genetics from the University of Namur (Belgium) under the supervision of feu Prof Jean Vandenhaute. He conducted post-doctoral training (1995-2001) with Prof David Tollervey in the Gene Expression program at the European Molecular Biology Laboratory (EMBL, Heidelberg) and The Welcome Trust Center for Cell Biology at the University of Edinburgh. Denis was recruited to a permanent position with the Belgian F.R.S./FNRS in 2001, and since then has worked as a Principal Investigator at the Institute of Molecular Biology & Medicine at the Université libre de Bruxelles. Denis is currently a Professor at the University of Brussels, and a Research Director with the F.R.S./FNRS. He is a co-founder and co-director of a preclinical imaging center, the Center for Microscopy and Molecular Imaging (Cmmi). He co-organized the International Ribosome Synthesis Meeting in 2012 (Banff, Canada), in 2015 (Brussels, Belgium), in 2018 (Magog, Canada), and in 2022 in Engelberg, Switzerland. Between 2017 and 2021, he acted as Dissemination Officer for the European COST action Epitran on Epitranscriptomics. In 2018, he joined the ULB-Cancer Research Center (U-CRC). Denis is giving lectures at the Bachelier and Master levels in Belgium (at U. Brussels, U. Charleroi, and U. Namur) and in France (at the University of Lorraine, in Nançy, where he is involved in an international Master on RNA Biochemistry). He is acting as a referee for journals in the field of Molecular and Cell Biology and for international funding agencies (American NSF, Austrian FWF, Belgian F.R.S/FNRS, British Wellcome Trust, Czech GACR, French ANR and INSERM, European Research Council, German DFG, Israel Science Foundation, Human Frontier Science Organization, Polish National Science Centre, Swiss NSF, etc.). Denis is a HUGO Gene Nomenclature Committee (HGNC) specialist advisor [Ribosomal biogenesis factors].