Publications

2024

100: … coming soon

2023

99: Leeman-Neill, R. J., Song, D., Bizarro, J., Wacheul, L., Rothschild, G., Singh, S., Yang, Y., Sarode, A. Y., Gollapalli, K., Wu, L., Zhang, W., Chen, Y., Lauring, M. C., Whisenant, D. E., Bhavsar, S., Lim, J., Swerdlow, S. H., Bhagat, G., Zhao, Q., Berchowitz, L. E., Lafontaine, D.L.J. , Wang, J., and Basu, U. (2023) “Acquired DNA element mutations retarget super-enhancer activity and protein synthesis during B cell lymphomagenesis “ Nature Genetics |DOI:10.1038/s41588-023-01561-1

98: Liberman, N., Rothi, M.H., Gerashchenko, M.V., Zorbas, C., Boulias, K., MacWhinnie, F.G., Ying, A.K., Taylor, A.F., Al Haddad, J., Shibuya, H., Roach, L., Dong, A., Dellacona, S., Lafontaine, D.L.J. , Gladyshev, V.N., and Lieberman Greer, E. (2023) “Intergenerational hormesis is regulated by heritable 18S rRNA methylation” Molecular Cell |DOI:10.1016/j.molcel.2023.08.014 Supplemental Data

97: Lafontaine D.L.J. (2023a) ” In Phase With The Nucleolus” Cell Research |DOI:10.1038/s41422-023-00801-7

96: Lafontaine D.L.J. (2023b) “When Two Became Three: Shaping the Nucleolus With Treacle” Cell Reports |DOI:10.1016/j.celrep.2023.113060

95: Zorbas, C., Soenmez, A., Léger, J., De Vleeschouwer, C., and Lafontaine D.L.J.(2023) “Detecting Material State Changes in the Nucleolus by Label-free Digital Holographic Microscopy” bioRXiv |DOI:10.1101/2023.03.17.533098 Supplemental Data

94: Cappe, B., Vadi, M., Sack, E., Wacheul, L., Verstraeten, B., Dufour, S., Franck, J., Xie, W., Impens, F., Hendrix, A., Lafontaine, D.L.J. , Vandenabeele, P., and Riquet, F.B. (2023) “Systematic compositional analysis of exosomal extracellular vesicles produced by cells undergoing apoptosis, necroptosis and ferroptosis”Journal of Extracellular Vesicles |DOI:10.1002/jev2.12365

93:  Caruso, M., Meurant, S., Detraux, D., Mathieu A., Gilson M., Dieu M., Fattaccioli, A., Demazy C., Najimi, M., Sokal, E., Arnould, T., Verfaillie C., Lafontaine D.L.J., and Renard P. (2023) ” The global downregulation of protein synthesis observed during hepatogenic differentiation is associated with a decrease in TOP mRNA translation” Stem Cell Reports |DOI:10.1016/j.stemcr.2022.11.020

92: Naarmann de Vries, I.S., Zorbas, C., Lemsara, A., Bencun, M., Schudy, S., Meder, B., Eschenbach, J., Lafontaine, D.L.J., and Dieterich, C. (2023) “Comprehensive identification of diverse ribosomal RNA modifications by targeted Nanopore direct RNA sequencing and JACUSA2” RNA Biology |DOI:doi.org/10.1080/15476286.2023.2248752 Supplemental Data

2022

91: Finet, O., Yague-Sanz, C., Kruger, L.K., Tran, P., Migeot, V., Louski, M., Nevers, A., Rougemaille, M., Sun, J., Ernst, F.G.M., Wacheul, L., Wéry, M., Morillon, A., Dedon, P., Lafontaine, D.L.J. , and Hermand, D. (2022) “Transcription-wide mapping of dihydrouridine (D) reveals that mRNA dihydrouridylation is required for meiotic chromosome segregation” Molecular Cell |DOI:10.1016/j.molcel.2021.11.003

90: O’Donohue, M.-F., Da Costa, L., Lezzerini, M., Unal, S., Joret, C., Bartels, M., Brilstra, E., Scheijde-Vermeulen, M., Wacheul, L., De Keersmaecker, K., Vereecke, S., Labarque, V., Saby, M., Lefevre, S.D., Platon, J., Montel-lehry, N., Laugero, N., Lacazette, E., van Gassen,K., Houtkooper, R.H., Simsek-Kiper, P.O., Leblanc, T., Yarali, N., Cetinkaya, A., Akarsu, N.A., Gleizes, P.E., Lafontaine, D.L.J. , and MacInnes, A.W. (2022) “HEATR3 variants impair nuclear import of uL18 (RPL5) and drive Diamond-Blackfan anemia” Blood |DOI:10.1182/blood.2021011846 Highlighted as a Commentary in Blood by Deena Iskander & Alan J. Warren

89: Pan, M., Zorbas, C., Sugaya, M., Ishiguro, K., Kato, M., Nishida, M., Zhang, H.-F., Candeias, M.M., Okamoto, A., Ishikawa, T., Soga, T., Aburatani, H., Sakai, J., Matsumura, Y., Suzuki, T., Proud, C.G., Lafontaine, D.L.J. , Osawa, T. (2022) “Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors” Nature Communications |DOI:doi.org/10.1101/2021.12.03.471189 Supplemental Data

88: Delhermite, J., Tafforeau, L., Sharma, S., Marchand, V., Wacheul, L., Lattuca, R., Desiderio, S., Motorin, Y., Bellefroid, E., Lafontaine, D.L.J. (2022) “Systematic mapping of rRNA 2’-O methylation during frog development and involvement of the methyltransferase Fibrillarin in eye and craniofacial development in Xenopus laevis” PLoS Genetics  |DOI:doi.org/10.1371/journal.pgen.1010012

87: Bortolin-Cavaillé, M.-L., Quillien, A., Thalalla Gamage, S., Thomas Justin, M., Sas-Chen, A., Sharma, S., Plisson-Chastang, C., Vandel, L., Blader, P., Lafontaine, D.L.J.  Schwartz, S., Meier, J.L., and Cavaillé, J. (2022) “Probing small ribosomal subunit RNA helix 45 acetylation across eukaryotic evolution” Nucleic Acids Research |DOI:doi.org/10.1101/2021.11.30.470322

86: Mathieu, V., Laguera, B., Masi, M., Dulanto, S.A., Bingham, T.W., Hernandez, L.W., Sarlah, D., Evidente, A., Lafontaine, D.L.J. , Kornienko, A., and Lane, M.A. (2022) “Amaryllidaceae alkaloids decrease the proliferation, invasion, and secretion of clinically relevant cytokines by cultured human colon cancer cells”  Biomolecules 12, 1267 | DOI: 10.3390/biom12091267

85: Planas-Sitjà, I., Deneubourg, J.-L., Lafontaine, D.L.J. , Wacheul, L., and Cronin, A.L. (2022) ” Differential gene expression correlates with behavioural polymorphism during collective behaviour in cockroaches”  Animals 12, 2354 | DOI:10.3390/ani12182354

2021

84: Qin, Y., Huttlin, E.L., Winsnes, C.F., Gosztyla, M.L., Wacheul, L., Kelly, M.R., Blue, S.M., Zheng, F., Chen, M., Schaffer, L.V., Licon, K., Bäckström, A., Pontano Vaites, L., Lee, J.J., Ouyang, W., Liu, S.N., Zhang, T., Silva, E., Park, J., Pitea, A., Kreisberg, J.F., Gygi, S.P., Ma, J., Harper, J.W., Yeo, G.W., Lafontaine, D.L.J. , Lundberg, E. and Ideker, T. (2021) “Mapping cell structure across scales by fusing protein images and interactions” Nature |DOI:10.1038/s41586-021-04115-9

83: Bizarro, J., Deryusheva, S., Wacheul, L., Gupta, V., Ernst, F.G.M., Lafontaine, D.L.J. , Gall, J., and Meier, U.T. (2021) “Nopp140-chaperoned 2′-O-methylation of small nuclear RNAs in Cajal bodies ensures splicing fidelity” Genes & Development |DOI:10.1101/gad.348660.121 Supplemental Data

82: Duchemin, A., O’Grady, T., Hanache, S., Méreau, A., Thiry, M., Wacheul, L., Michaux, C., Perpete, E., Hervouet, E., Peixoto, P., Ernst, F.G.M., Audic, Y., Dequiedt, F., Lafontaine, D.L.J. , Mottet, D. (2021) “DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity” Nature Communications |DOI:10.1038/s41467-021-26932-2

81: Sönmez, A., Mustafa, R., Ryll,S.T., Tuorto, F., Wacheul, W., Ponti, D., Litke. C., Hering, T., Kojer, K., Koch, J., Pitzer, C.,Kirsch, J., Neueder, A., Kreiner, G., Lafontaine, D.L.J.  Orth, M., Liss, B., and Parlato, R.(2021) “Nucleolar stress controls mutant Huntingtin toxicity and monitors Huntington’s disease progression”  Cell Death and Disease |DOI:10.1101/2021.07.09.451766

80: Barros-Silva, D., Klavert, J., Jenster, G., Jeronimo, C., Lafontaine, D.L.J.,and Martens-Uzunova, E.S. (2021) “The role of OncoSnoRNAs and Ribosomal RNA methylation in Cancer” RNA Biology |DOI:10.1080/15476286.2021.1991167

79: Shrimp, J.H, Jing. Y., Gamage, S.T., Nelson K.M., Han, J., Bryson, K.M., Montgomery, D.C., Thomas, J.M., Nance, K.D., Sharma, S., Fox, S.D., Andressen, T., Sinclair, W.R., Wu, H., Allali-Hasssani, A., Senisterra, G., Vedadi, M., Lafontaine, D.L.J., Dahlin, J.L., Marmortsein, R., Walters, M.A., Meier, J.L. (2020) “Remodelin is a cryptic assay interference chemotype that does not inhibit NAT10-dependent cytidine acetylation” ACS Medicinal Chemistry Letters |DOI:10.1021/acsmedchemlett.0c00193 Supplemental Data

78: Thelen, N., Defourny, J., Lafontaine, D.L.J. , and Thiry, M. (2021) “Visualization of chromatin in the yeast nucleus and nucleolus using hyperosmotic shock” International Journal of Molecular Sciences |DOI:10.3390/ijms22031132

77: Dunn-Davies, H., Dudnakova, T., Langhendries, J.-L., Watkins, N., Lafontaine, D.L.J. , and Tollervey, D. (2021) “Systematic mapping of small nucleolar RNA targets in human cells” bioRXiv |DOI:10.1101/2021.07.22.451324

2020

76: Lafontaine, D.L.J. , Riback,J.A., Bascetin, R., and Brangwynne, C.P. (2020) “The nucleolus as a multiphase liquid condensate” Nature Reviews Molecular Cell Biology |DOI:10.1038/s41580-020-0272-6

75: Leismann, J., Spagnuolo, M., Pradhan, M., Wacheul, L., Vu, M.A., Musheev, M., Mier, P., Andrade-Navarro, M.A., Graille, M., Niehrs, C., Lafontaine, D.L.J. , Roignant, J.-Y. (2020) “The 18S ribosomal RNA m6A methyltransferase Mettl5 is required for normal walking behavior in Drosophila” EMBO Reports e49443 |DOI:10.15252/embr.201949443 Supplemental Data

74: Heissenberger, C., Krammer, T.L., Rollins, J.A., Nagelreiter, F., Stocker, I., Wacheul, L., Shpylovyi, A., Snow, S., Grillari, J., Rogers, A., Lafontaine, D.L.J. , Schosserer, M. (2020) “The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans” eLIFE |DOI:10.7554/eLife.56205

73: Lacoux, C., Wacheul, L., Saraf, K., Pythoud, N., Huvelle, E., Figaro, S., Graille, M., Carapito, C., Lafontaine, D.L.J. , and Heurgue-Hamard, V. (2020) “The catalytic activity of the translation termination factor methyltransferase Mtq2-Trm112 complex is required for large ribosomal subunit biogenesis” Nucleic Acids Research |DOI:10.1093/nar/gkaa972 Supplemental Data

72: Badrock, A.P., Uggenti, C., Wacheul, L., Crilly, S., Jenkinson, E.M., Rice, G.I., Kasher, P.R., Lafontaine, D.L.J.  Crow, Y.J., O’Keefe, R.T. (2020) “Analysis of U8 snoRNA Variants in Zebrafish Reveals how Bi-allelic Variants Cause Leukoencephalopathy with Calcifications and Cysts” The American Journal of Human Genetics 106: 694-706 |DOI:10.1016/j.ajhg.2020.04.003 Supplemental Data

71: Clerget G., Bourguignon-Igel V., Marmier-Gourrier N., Rolland N., Wacheul L., Manival X., Charron C., Kufel J., Méreau A., Senty-Ségault V., Tollervey D., Lafontaine D.L.J, Branlant C. and Rederstorff M. (2020) “Synergistic defects in pre-rRNA processing from mutations in the U3 snoRNA and U3-specific protein Rrp9” Nucleic Acids Research 48(7): 3848-3868 |DOI:10.1093/nar/gkaa066 Supplemental data

70: Marchand, V., Pichot, F., Neybecker, P., Ayadi, L., Bourguignon-Igel, V., Wacheul, L., Lafontaine, D.L.J., Pinzano,A., Helm, M., and Motorine, Y. (2020) “HydraPsiSeq, a method for systematic and quantitative mapping of pseudouridines in RNA” Nucleic Acids Research |DOI:10.1093/nar/gkaa769

2019

69: Lafontaine, D.L.J. (2019) “Birth of nucleolar compartments: Phase separation-driven ribosomal RNA sorting and processing” Molecular Cell 76: 694-696 |DOI:10.1016/j.molcel.2019.11.015

68: Zhu, L., Richardson, T.M., Wacheul, L., Wei, M.-T., Feric, M., Whitney, G., Lafontaine, D.L.J. , Clifford P. Brangwynne (2019) “Controlling the material properties and rRNA processing function of the nucleolus using light” PNAS U.S.A. |DOI:10.1073/pnas/1903870116Supplemental Data

67: Tran, N.V., Ernst, F.G.M., Hawley, B.R., Zorbas, C., Ulryck, N., Bohnsack, K.E., Bohnsack, M.T., Jaffrey, S.R., Graille, M. Lafontaine, D.L.J.  (2019) “The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112” Nucleic Acids Research |DOI:10.1093/nar/gkz619 nominated as Nucleic Acids Research Breakthrough ArticleSupplemental Data

66: Roychowdhury, A., Joret, C., Bourgeois, G., Heurgué-Hamard, V., Lafontaine, D.L.J. , and Graille, M. (2019) “The DEAH-box RNA helicase Dhr1 contains a remarkable carboxyl terminal domain essential for small ribosomal subunit biogenesis” Nucleic Acids Research |DOI:10.1093/nar/gkz529Supplemental Data

65: Catez, F., Dalla Venezia, N., Marcel, V., Zorbas, C., Lafontaine, D.L.J. , and Diaz, J.J. (2019) “Ribosome biogenesis: an emerging druggable pathway for cancer therapeutics” Biochemical Pharmacology |DOI:10.1016/j.bcp.2018.11.014

2018

64: Marchand, V., Ayadi, L., Ernst, F.G., Hertler, J., Bourguignon-Igel, Valérie, Galvanin, A., Kotter, A., Helm, M. Lafontaine, D.L.J. , and Motorin, Y. (2018) “AlkAniline-Seq: profiling of m7G and m3C RNA modifications at single nucleotide resolution” Angewandte Chemie |DOI:10.1002/anie.201810946Supplemental Data

63: Stamatopoulou, V., Parisot, P., De Vleeschouwer, C., Lafontaine, D.L.J. (2018) “Use of the iNo score to discriminate normal from altered nucleolar morphology, with applications in basic cell biology and potential in human disease diagnostics” Nature Protocols |DOI:10.1038/s41596-018-0044-3Supplemental Data

62: Sharma, S., Hartmann, J.D., Watzinger, P., Klepper, A., Peifer, C., Koetter, P., Lafontaine, D.L.J., Entian, K.-D. (2018) “A single N1-methyladenosine on the large ribosomal subunit rRNA impacts locally its structure and the translation of key metabolic enzymes” Scientific Reports 8: 11904 |DOI:10.1038/s41598-018-30383-zSupplemental Data

61: Jantsch, M. et al. (2018) “Positioning Europe for the EPITRANSCRIPTOMICS challenge” RNA Biology |DOI:10.1080/15476286.2018.1460996

60: Pellegrino, S., Meyer, M., Zorbas, C., Boutcha, S.A., Saraf, K., Pelly, S.C., Yusupova, G., Evidente, A., Mathieu, V., Kornienko, A. Lafontaine, D.L.J., Yusupov, M. (2018) “The Amaryllidaceae alkaloid haemanthamine binds the eukaryotic ribosome to repress cancer cell growth” Structure 26: 1-10 |DOI:10.1016/j.str.2018.01.009Supplemental Data

59: Vendramin, R., Verheyden, Y., Hideaki, I., Lucas, G., Nicolas, E., Saraf, K., Delli Ponti, R., Armaos, A., Izumikawa, K., Mestdagh, P. Lafontaine, D.L.J., Tartaglia, G. G., Takahashi, N., Marine, J.-C., Leucci, E. (2018) “SAMMSON fosters cancer cell fitness by enhancing concertedly mitochondrial and cytosolic translation” Nature Structural & Molecular Biology |DOI:10.1038/s41594-018-0143-4Supplemental Data

2017

58: Sharma, S., Marchand, V., Motorin, Y., Lafontaine, D.L.J. (2017) “Identification of sites of 2’-O-methylation vulnerability in human ribosomal RNAs by systematic mapping” Scientific Reports 7: 11490 |DOI:10.1038/s41598-017-09734-9 Supplemental Data

57: Sharma, S., Yang, J., van Nues, R., Watzinger, P., Kötter, P., Lafontaine, D.L.J., Granneman, S., Entian, K.-D. (2017) “Specialized box C/D snoRNPs act as antisense guides to target RNA base acetylation” PLoS Genetics |DOI:10.1371/journal.pgen.1006804Supplemental Data

2016

56: Nicolas, E., Parisot, P., Pinto-Monteiro, C., de Walque, R., De Vleeschouwer, C., Lafontaine, D.L.J. (2016) “Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress” Nature Communications |DOI:10.1038/ncomms11390Supplemental Data

55: Langhendries, J.-L., Nicolas, E., Doumont, G., Goldman, S., Lafontaine, D.L.J. (2016) “The human box C/D snoRNAs U3 and U8 are required for pre-rRNA processing and tumorigenesis” Oncotarget |DOI:10.18632/Oncotarget.11148

54: Bar, D.Z., Charar, C., Dorfman, J., Yadid, T., Tafforeau, L., Lafontaine, D.L.J., Gruenbaum, Y. (2016) “Cell size and fat content of dietary restricted Caenorhabditis elegans are regulated by ATX-2, a novel mTOR repressor” PNAS U.S.A. |DOI:10.1073/pnas.1512156113

53: Leucci, E., Vendramin, R., Spinazzi, M., Laurette, P., Fiers, M., Wouters, J., Radaelli, E., Eyckerman, S., Leonelli,C., Vanderheyden,K., Rogiers,A., Hermans, E., Baatsen, P., Aerts, S., Amant, F., Van Aelst, S., van den Oord, J., de Strooper, B., Davidson, I., Lafontaine, D.L.J., Gevaert, K., Vandesompele, J., Mestdagh, P., Marine, J.-C. (2016) “Melanoma addiction to the long non-coding RNA SAMMSON” Nature 531: 518-522

52: Sobecki, M., Mrouj, K., Camasses, A., Parisis, N., Nicolas, E., Lleres, D., Gerbe, F., Prieto, S., Krasinska, L., David, A., Eguren, M., Birling, M.-C., Urbach, S., Hem, S., Déjardin, J., Malumbres, M., Jay, P., Dulic, V., Lafontaine, D.L.J., Feil, R., Fisher, D. “The cell proliferation antigen Ki-67 organises heterochromatin” Elife 2016 Mar 7;5. pii: e13722. |DOI:10.7554/eLife.13722.

51: Sloan, K.E., Warda, A.S., Sharma, S., Entian, K.-D., Lafontaine, D.L.J., Bohnsack, M. (2016) “Tuning the ribosome: the influence of rRNA modification on eukaryotic ribosome biogenesis and function” RNA Biology |DOI:10.1080/15476286.2016.1259781

50: Meyer, B., Wurm, J.P., Sharma, S., Immer, C., Pogoryelov, D., Kötter, P., Lafontaine, D.L.J., Wöhnert, J., Entian, K.-D. (2016) “Ribosome biogenesis factor Tsr3 is the aminocarboxypropyltransferase responsible for 18S rRNA hypermodification in yeast and humans” Nucleic Acids Research |DOI: 10.1093/nar/gkw244

2015

49: Lafontaine, D.L.J. (2015). “Non-coding RNAs in ribosome synthesis and function.” Nature Structural & Molecular Biology 21(1): 11-19. Special Focus on ncRNAs. Editorial

48: Sharma, S., Lafontaine, D.L.J. “View From A Bridge: A New Perspective on Eukaryotic rRNA Base Modification” Trends in Biochemical Sciences Oct. 2015

47: Hauenschild, R., Tserovski, L., Schmid, K., Thüring, K., Winz, M.L., Sharma, S., Entian K.-D., Wacheul, L., Lafontaine, D.L.J., Anderson, J., Alfonzo, J., Hildebrandt, A., Jäschke, A., Motorin, Y., Helm, M. “The reverse transcription signature of N-1-methyladenosine in RNA-seq is sequence dependent” Nucleic Acids Research 2015. Sep 13. pii: gkv895. [Epub ahead of print]

46: Zorbas, C., Nicolas, E., Wacheul, L., Huvelle, E., Heurgué-Hamard, V., Lafontaine, D.L.J. (2015) “The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis.” Molecular Biology of the Cell 26: 2080-2095.

45: Sharma, S., Langhendries, J.-L., Watzinger, P., Kötter, P., Entian, K.-D., Lafontaine, D.L.J. (2015) “Yeast Kre33 and Human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1”. Nucleic Acids Research doi: 10.1093/nar/gkv075

2014

44: Létoquart, J., Huvelle, E., Wacheul, L., Bourgeois, G., Zorbas, C., Graille, M., Heurgué-Hamard, V., Lafontaine, D.L.J. (2014). “Structural and functional studies of Bud23-Trm112 reveal 18S rRNA N7-G1575 methylation occurs on late 40S precursor ribosomes.” PNAS U.S.A. Dec 23;111(51):E5518-26. doi: 10.1073/pnas.1413089111. Epub 2014 Dec 8.

43: Stanicki, D., Boutry, S., Laurent, S., Wacheul, L., Nicolas, E., Crombez, D., Vander Elst, L., Lafontaine, D.L.J. and Muller, R. N. (2014). “Carboxy-silane coated iron oxide nanoparticles: a convenient platform for cellular and small animal imaging.” J Mater Chem B 2: 387-397. Last two authors are corresponding authors.

42: Ban, N., Beckmann, R., Cate, J. H., Dinman, J. D., Dragon, F., Ellis, S. R., Lafontaine, D.L.J., Lindahl, L., Liljas, A., Lipton, J. M., McAlear, M. A., Moore, P. B., Noller, H. F., Ortega, J., Panse, V. G., Ramakrishnan, V., Spahn, C. M., Steitz, T. A., Tchorzewski, M., Tollervey, D., Warren, A. J., Williamson, J. R., Wilson, D., Yonath, A. and Yusupov, M. (2014). “A new system for naming ribosomal proteins.” Current Opinion Structural Biology 24: 165-169.

2013

41: Tafforeau, L., Zorbas, C., Langhendries, J. L., Mullineux, S. T., Stamatopoulou, V., Mullier, R., Wacheul, L. and Lafontaine, D.L.J. (2013). “The complexity of human ribosome biogenesis revealed by systematic nucleolar screening of Pre-rRNA processing factors.” Molecular Cell 51: 539-551. |DOI: 10.1016/j.molcel.2013.08.011Supplemental Data

2012

40: Schillewaert, S., Wacheul, L., Lhomme, F. and Lafontaine, D.L.J. (2012). “The evolutionarily conserved protein Las1 is required for pre-rRNA processing at both ends of ITS2.” Mol Cell Biol 32: 430-444.

39: Figaro, S., Wacheul, L., Schillewaert, S., Graille, M., Huvelle, E., Mongeard, R., Zorbas, C., Lafontaine, D.L.J. and Heurgue-Hamard, V. (2012). “Trm112 is required for Bud23-mediated methylation of the 18S rRNA at position G1575.” Mol Cell Biol 32: 2254-2267. Equal contribution of last two authors.

38: Mullineux, S. T. and Lafontaine, D. L. J. (2012). “Mapping the cleavage sites on mammalian pre-rRNAs: where do we stand?” Biochimie 94: 1521-1532.

37: Serviene, E., Luksa, J., Orentaite, I., Lafontaine, D.L.J. and Urbonavicius, J. (2012). “Screening the budding yeast genome reveals unique factors affecting K2 toxin susceptibility.” PLoS One 7: e50779. Equal contribution of last two authors.

2011

36:Lamaye, F., Galliot, S., Alibardi, L., Lafontaine, D.L.J. and Thiry, M. (2011). “Nucleolar structure across evolution: the transition between bi- and tri-compartmentalized nucleoli lies within the class Reptilia.” Journal of Structural Biology 174: 352-359.

35: Thiry, M., Lamaye, F. and Lafontaine, D.L.J. (2011). “The nucleolus: when 2 became 3.” Nucleus 2: 289-293.

34: Leporé, N. and Lafontaine, D.L.J. (2011). “A functional interface at the rDNA connects rRNA synthesis, pre-rRNA processing and nucleolar surveillance in budding yeast.” PLoS One 6: e24962.

2010

33: Lafontaine, D.L.J. (2010). “A ‘garbage can’ for ribosomes: how eukaryotes degrade their ribosomes.” Trends Biochemical Sciences 35: 267-277.

32: Hernandez-Verdun, D., Roussel, P., Thiry, M., Sirri, V. and Lafontaine, D.L.J. (2010). “The nucleolus: structure/function relationship in RNA metabolism.” Wiley Interdisciplinary Reviews: RNA 1: 415-431.

31: Leporé, N. and Lafontaine, D.L.J. (2010). “[<< Catch me if you can >>: how the structural and functional integrity of eukaryotic RNA molecules is monitored by surveillance mechanisms].” Medecine/Sciences (Paris) 26: 259-266.

2009

30: Wery, M., Ruidant, S., Schillewaert, S., Lepore, N. and Lafontaine, D.L.J. (2009). “The nuclear poly(A) polymerase and Exosome cofactor Trf5 is recruited cotranscriptionally to nucleolar surveillance.” RNA 15: 406-419.

2008

29: Vanrobays, E., Leplus, A., Osheim, Y. N., Beyer, A. L., Wacheul, L. and Lafontaine, D.L.J. (2008). “TOR regulates the subcellular distribution of DIM2, a KH domain protein required for cotranscriptional ribosome assembly and pre-40S ribosome export.” RNA 14: 2061-2073.

28: Qiu, H., Eifert, J., Wacheul, L., Thiry, M., Berger, A. C., Jakovljevic, J., Woolford, J. L., Jr., Corbett, A. H., Lafontaine, D.L.J., Terns, R. M. and Terns, M. P. (2008). “Identification of genes that function in the biogenesis and localization of small nucleolar RNAs in Saccharomyces cerevisiae.” Mol Cell Biol 28: 3686-3699.

2007

27: Chedin, S., Laferte, A., Hoang, T., Lafontaine, D.L.J., Riva, M. and Carles, C. (2007). “Is ribosome synthesis controlled by pol I transcription?” Cell Cycle 6: 11-15.

2005

26: Thiry, M. and Lafontaine, D.L.J. (2005). “Birth of a nucleolus: the evolution of nucleolar compartments.” Trends Cell Biology 15: 194-199.

25: Hoang, T., Peng, W. T., Vanrobays, E., Krogan, N., Hiley, S., Beyer, A. L., Osheim, Y. N., Greenblatt, J., Hughes, T. R. and Lafontaine, D.L.J. (2005). “Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction.” Mol Cell Biol 25: 5523-5534.

2004

24: Vanrobays, E., Gelugne, J. P., Caizergues-Ferrer, M. and Lafontaine, D.L.J. (2004). “Dim2p, a KH-domain protein required for small ribosomal subunit synthesis.” RNA 10: 645-656.

23: Lafontaine, D.L.J. (2004). Eukaryotic ribosome synthesis. Protein Synthesis and Ribosome Structure. K. Nierhaus, Wiley-InterScience: 107-143.

22: Colau, G., Thiry, M., Leduc, V., Bordonne, R. and Lafontaine, D.L.J. (2004). “The small nucle(ol)ar RNA cap trimethyltransferase is required for ribosome synthesis and intact nucleolar morphology.” Mol Cell Biol 24: 7976-7986.

2002

21: Verheggen, C., Lafontaine, D.L.J., Samarsky, D., Mouaikel, J., Blanchard, J. M., Bordonne, R. and Bertrand, E. (2002). “Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments.” EMBO J 21: 2736-2745.

2001

20: Lafontaine, D.L.J. and Tollervey, D. (2001). “The function and synthesis of ribosomes.” Nature Reviews Molecular Cellular Biology 2: 514-520.

19: Verheggen, C., Mouaikel, J., Thiry, M., Blanchard, J. M., Tollervey, D., Bordonne, R., Lafontaine, D.L.J. and Bertrand, E. (2001). “Box C/D small nucleolar RNA trafficking involves small nucleolar RNP proteins, nucleolar factors and a novel nuclear domain.” EMBO J 20: 5480-5490. Equal contribution of last two authors.

18: Senger, B., Lafontaine, D.L.J., Graindorge, J. S., Gadal, O., Camasses, A., Sanni, A., Garnier, J. M., Breitenbach, M., Hurt, E. and Fasiolo, F. (2001). “The nucle(ol)ar Tif6p and Efl1p are required for a late cytoplasmic step of ribosome synthesis.” Molecular Cell 8: 1363-1373.

17: Lafontaine, D.L.J. and Tollervey, D. (2001). Ribosomal RNA. Encyclopedia of Life Sciences (http://www.els.net), MacMillan – Nature

16: Dez, C., Henras, A., Faucon, B., Lafontaine, D.L.J., Caizergues-Ferrer, M. and Henry, Y. (2001). “Stable expression in yeast of the mature form of human telomerase RNA depends on its association with the box H/ACA small nucleolar RNP proteins Cbf5p, Nhp2p and Nop10p.” Nucleic Acids Res 29: 598-603.

2000

15: Lafontaine, D.L.J. and Tollervey, D. (2000). “Synthesis and assembly of the box C+D small nucleolar RNPs.” Mol Cell Biol 20: 2650-2659.

14: Kufel, J., Allmang, C., Chanfreau, G., Petfalski, E., Lafontaine, D. L. J. and Tollervey, D. (2000). “Precursors to the U3 small nucleolar RNA lack small nucleolar RNP proteins but are stabilized by La binding.” Mol Cell Biol 20: 5415-5424.

13: Colley, A., Beggs, J. D., Tollervey, D. and Lafontaine, D.L.J. (2000). “Dhr1p, a putative DEAH-box RNA helicase, is associated with the box C+D snoRNP U3.” Mol Cell Biol 20: 7238-7246.

1999

12: Massenet, S., Motorin, Y., Lafontaine, D.L.J., Hurt, E. C., Grosjean, H. and Branlant, C. (1999). “Pseudouridine mapping in the Saccharomyces cerevisiae spliceosomal U small nuclear RNAs (snRNAs) reveals that pseudouridine synthase pus1p exhibits a dual substrate specificity for U2 snRNA and tRNA.” Mol Cell Biol 19: 2142-2154.

11: Lafontaine, D.L.J. and Tollervey, D. (1999). “Nop58p is a common component of the box C+D snoRNPs that is required for snoRNA stability.” RNA 5: 455-467.

10: Fortes, P., Kufel, J., Fornerod, M., Polycarpou-Schwarz, M., Lafontaine, D.L.J., Tollervey, D. and Mattaj, I. W. (1999). “Genetic and physical interactions involving the yeast nuclear cap-binding complex.” Mol Cell Biol 19: 6543-6553.

1998

9: Lafontaine, D.L.J., Bousquet-Antonelli, C., Henry, Y., Caizergues-Ferrer, M. and Tollervey, D. (1998). “The box H + ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase.” Genes & Development 12: 527-537.

8: Lafontaine, D.L.J. and Tollervey, D. (1998). “Birth of the snoRNPs: the evolution of the modification-guide snoRNAs.” Trends Biochem Sci23: 383-388.

7: Lafontaine, D.L.J., Preiss, T. and Tollervey, D. (1998). “Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis?” Mol Cell Biol 18: 2360-2370.

6: Lafontaine, D.L.J. and Tollervey, D. (1998). Regulatory aspects of rRNA modifications and pre-rRNA processing. Modification and editing of RNA. H. Grosjean and R. Benne. Washington, ASM Press: 281-288.

1997

5: Housen, I., Demonte, D., Lafontaine, D.L.J. and Vandenhaute, J. (1997). “Cloning and characterization of the KlDIM1 gene from Kluyveromyces lactis encoding the m2(6)A dimethylase of the 18S rRNA.” Yeast 13: 777-781.

1996

4: Lafontaine, D.L.J. and Tollervey, D. (1996). “One-step PCR mediated strategy for the construction of conditionally expressed and epitope tagged yeast proteins.” Nucleic Acids Research 24: 3469-3471.

1995

3: Lafontaine, D.L.J., Vandenhaute, J. and Tollervey, D. (1995). “The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast.” Genes & Development 9: 2470-2481.

2: Lafontaine, D.L.J. and Tollervey, D. (1995). “Trans-acting factors in yeast pre-rRNA and pre-snoRNA processing.” Biochemistry and Cell Biology 73: 803-812.

1994

1: Lafontaine, D.L.J., Delcour, J., Glasser, A. L., Desgres, J. and Vandenhaute, J. (1994). “The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3′-terminal loop of 18 S rRNA is essential in yeast.” Journal of Molecular Biology 241: 492-497.

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