90: O’Donohue, M.-F., Da Costa, L., Lezzerini, M., Unal, S., Joret, C., Bartels, M., Brilstra, E., Scheijde-Vermeulen, M., Wacheul, L., De Keersmaecker, K., Vereecke, S., Labarque, V., Saby, M., Lefevre, S.D., Platon, J., Montel-lehry, N., Laugero, N., Lacazette, E., van Gassen,K., Houtkooper, R.H., Simsek-Kiper, P.O., Leblanc, T., Yarali, N., Cetinkaya, A., Akarsu, N.A., Gleizes, P.E., Lafontaine, D.L.J. , and MacInnes, A.W. (2022) “HEATR3 variants impair nuclear import of uL18 (RPL5) and drive Diamond-Blackfan anemia” Blood On-line |DOI:10.1182/

89: Pan, M., Zorbas, C., Sugaya, M., Ishiguro, K., Kato, M., Nishida, M., Zhang, H.-F., Candeias, M.M., Okamoto, A., Ishikawa, T., Soga, T., Aburatani, H., Sakai, J., Matsumura, Y., Suzuki, T., Proud, C.G., Lafontaine, D.L.J. , Osawa, T. (2022) “Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors” Nature Communications (In The Press)  | Supplemental Data

88: Finet, O., Yague-Sanz, C., Kruger, L.K., Tran, P., Migeot, V., Louski, M., Nevers, A., Rougemaille, M., Sun, J., Ernst, F.G.M., Wacheul, L., Wéry, M., Morillon, A., Dedon, P., Lafontaine, D.L.J. , and Hermand, D. (2022) “Transcription-wide mapping of dihydrouridine (D) reveals that mRNA dihydrouridylation is required for meiotic chromosome segregation” Molecular Cell |DOI:10.1016/j.molcel.2021.11.003

87: Delhermite, J., Tafforeau, L., Sharma, S., Marchand, V., Wacheul, L., Lattuca, R., Desiderio, S., Motorin, Y., Bellefroid, E., Lafontaine, D.L.J. (2022) “Systematic mapping of rRNA 2’-O methylation during frog development and involvement of the methyltransferase Fibrillarin in eye and craniofacial development in Xenopus laevis” PLoS Genetics  |

86: Bortolin-Cavaillé, M.-L., Quillien, A., Thalalla Gamage, S., Thomas Justin, M., Sas-Chen, A., Sharma, S., Plisson-Chastang, C., Vandel, L., Blader, P., Lafontaine, D.L.J.  Schwartz, S., Meier, J.L., and Cavaillé, J. (2022) “Probing small ribosomal subunit RNA helix 45 acetylation across eukaryotic evolution” Nucleic Acids Research (In The Press) |


85: Qin, Y., Huttlin, E.L., Winsnes, C.F., Gosztyla, M.L., Wacheul, L., Kelly, M.R., Blue, S.M., Zheng, F., Chen, M., Schaffer, L.V., Licon, K., Bäckström, A., Pontano Vaites, L., Lee, J.J., Ouyang, W., Liu, S.N., Zhang, T., Silva, E., Park, J., Pitea, A., Kreisberg, J.F., Gygi, S.P., Ma, J., Harper, J.W., Yeo, G.W., Lafontaine, D.L.J. , Lundberg, E. and Ideker, T. (2021) “Mapping cell structure across scales by fusing protein images and interactions” Nature |DOI:10.1038/s41586-021-04115-9

84: Duchemin, A., O’Grady, T., Hanache, S., Méreau, A., Thiry, M., Wacheul, L., Michaux, C., Perpete, E., Hervouet, E., Peixoto, P., Ernst, F.G.M., Audic, Y., Dequiedt, F., Lafontaine, D.L.J. , Mottet, D. (2021) “DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity” Nature Communications |DOI:10.1038/s41467-021-26932-2

83: Naarmann de Vries, I.S., Zorbas, C., Lemsara, A., Bencun, M., Schudy, S., Meder, B., Eschenbach, J., Lafontaine, D.L.J. , and Dieterich, C. (2021)
“Deep assessment of human disease-associated ribosomal RNA modifications using Nanopore direct RNA sequencing” bioRXiv |

82: Barros-Silva, D., Klavert, J., Jenster, G., Jeronimo, C., Lafontaine, D.L.J., and Martens-Uzunova, E.S. (2021) “The role of OncoSnoRNAs and Ribosomal RNA methylation in Cancer” RNA Biology |DOI:10.1080/15476286.2021.1991167  

81: Dunn-Davies, H., Dudnakova, T., Langhendries, J.-L., Watkins, N., Lafontaine, D.L.J. , and Tollervey, D. (2021) “Systematic mapping of small nucleolar RNA targets in human cells” bioRXiv |DOI:10.1101/2021.07.22.451324

80: Bizarro, J., Deryusheva, S., Wacheul, L., Gupta, V., Ernst, F.G.M., Lafontaine, D.L.J. , Gall, J., and Meier, U.T. (2021) “Nopp140-chaperoned 2′-O-methylation of small nuclear RNAs in Cajal bodies ensures splicing fidelity” Genes & Development |DOI:10.1101/gad.348660.121 Supplemental Data

79: Sönmez, A., Mustafa, R., Ryll,S.T., Tuorto, F., Wacheul, W., Ponti, D., Litke. C., Hering, T., Kojer, K., Koch, J., Pitzer, C.,Kirsch, J., Neueder, A., Kreiner, G., Lafontaine, D.L.J.  Orth, M., Liss, B., and Parlato, R.(2021) “Nucleolar stress controls mutant Huntingtin toxicity and monitors Huntington’s disease progression”  Cell Death and Disease |DOI:10.1101/2021.07.09.451766

78: Thelen, N., Defourny, J., Lafontaine, D.L.J. , and Thiry, M. (2021) “Visualization of chromatin in the yeast nucleus and nucleolus using hyperosmotic shock” International Journal of Molecular Sciences |DOI:10.3390/ijms22031132


77: Lafontaine, D.L.J. , Riback,J.A., Bascetin, R., and Brangwynne, C.P. (2020) “The nucleolus as a multiphase liquid condensate” Nature Reviews Molecular Cell Biology |DOI:10.1038/s41580-020-0272-6

76: Heissenberger, C., Krammer, T.L., Rollins, J.A., Nagelreiter, F., Stocker, I., Wacheul, L., Shpylovyi, A., Snow, S., Grillari, J., Rogers, A., Lafontaine, D.L.J. , Schosserer, M. (2020) “The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans” eLIFE |DOI:10.7554/eLife.56205

75: Leismann, J., Spagnuolo, M., Pradhan, M., Wacheul, L., Vu, M.A., Musheev, M., Mier, P., Andrade-Navarro, M.A., Graille, M., Niehrs, C., Lafontaine, D.L.J. , Roignant, J.-Y. (2020) “The 18S ribosomal RNA m6A methyltransferase Mettl5 is required for normal walking behavior in Drosophila” EMBO Reports e49443 |DOI:10.15252/embr.201949443 Supplemental Data

74: Lacoux, C., Wacheul, L., Saraf, K., Pythoud, N., Huvelle, E., Figaro, S., Graille, M., Carapito, C., Lafontaine, D.L.J. , and Heurgue-Hamard, V. (2020) “The catalytic activity of the translation termination factor methyltransferase Mtq2-Trm112 complex is required for large ribosomal subunit biogenesis” Nucleic Acids Research |DOI:10.1093/nar/gkaa972 Supplemental Data

73: Marchand, V., Pichot, F., Neybecker, P., Ayadi, L., Bourguignon-Igel, V., Wacheul, L., Lafontaine, D.L.J., Pinzano,A., Helm, M., and Motorine, Y. (2020) “HydraPsiSeq, a method for systematic and quantitative mapping of pseudouridines in RNA” Nucleic Acids Research |DOI:10.1093/nar/gkaa769

72: Badrock, A.P., Uggenti, C., Wacheul, L., Crilly, S., Jenkinson, E.M., Rice, G.I., Kasher, P.R., Lafontaine, D.L.J.  Crow, Y.J., O’Keefe, R.T. (2020) “Analysis of U8 snoRNA Variants in Zebrafish Reveals how Bi-allelic Variants Cause Leukoencephalopathy with Calcifications and Cysts” The American Journal of Human Genetics 106: 694-706 |DOI:10.1016/j.ajhg.2020.04.003 Supplemental Data

71: Clerget G., Bourguignon-Igel V., Marmier-Gourrier N., Rolland N., Wacheul L., Manival X., Charron C., Kufel J., Méreau A., Senty-Ségault V., Tollervey D., Lafontaine D.L.J, Branlant C. and Rederstorff M. (2020) “Synergistic defects in pre-rRNA processing from mutations in the U3 snoRNA and U3-specific protein Rrp9” Nucleic Acids Research 48(7): 3848-3868 |DOI:10.1093/nar/gkaa066 Supplemental data

70: Shrimp, J.H, Jing. Y., Gamage, S.T., Nelson K.M., Han, J., Bryson, K.M., Montgomery, D.C., Thomas, J.M., Nance, K.D., Sharma, S., Fox, S.D., Andressen, T., Sinclair, W.R., Wu, H., Allali-Hasssani, A., Senisterra, G., Vedadi, M., Lafontaine, D.L.J., Dahlin, J.L., Marmortsein, R., Walters, M.A., Meier, J.L. (2020) “Remodelin is a cryptic assay interference chemotype that does not inhibit NAT10-dependent cytidine acetylation” ACS Medicinal Chemistry Letters |DOI:10.1021/acsmedchemlett.0c00193 Supplemental Data


69: Lafontaine, D.L.J. (2019) “Birth of nucleolar compartments: Phase separation-driven ribosomal RNA sorting and processing” Molecular Cell 76: 694-696 |DOI:10.1016/j.molcel.2019.11.015

68: Zhu, L., Richardson, T.M., Wacheul, L., Wei, M.-T., Feric, M., Whitney, G., Lafontaine, D.L.J. , Clifford P. Brangwynne (2019) “Controlling the material properties and rRNA processing function of the nucleolus using light” PNAS U.S.A. |DOI:10.1073/pnas/1903870116 Supplemental Data

67: Tran, N.V., Ernst, F.G.M., Hawley, B.R., Zorbas, C., Ulryck, N., Bohnsack, K.E., Bohnsack, M.T., Jaffrey, S.R., Graille, M. Lafontaine, D.L.J.  (2019) “The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112” Nucleic Acids Research |DOI:10.1093/nar/gkz619 nominated as Nucleic Acids Research Breakthrough Article Supplemental Data

66: Roychowdhury, A., Joret, C., Bourgeois, G., Heurgué-Hamard, V., Lafontaine, D.L.J. , and Graille, M. (2019) “The DEAH-box RNA helicase Dhr1 contains a remarkable carboxyl terminal domain essential for small ribosomal subunit biogenesis” Nucleic Acids Research |DOI:10.1093/nar/gkz529 Supplemental Data

65: Catez, F., Dalla Venezia, N., Marcel, V., Zorbas, C., Lafontaine, D.L.J. , and Diaz, J.J. (2019) “Ribosome biogenesis: an emerging druggable pathway for cancer therapeutics” Biochemical Pharmacology |DOI:10.1016/j.bcp.2018.11.014


64: Marchand, V., Ayadi, L., Ernst, F.G., Hertler, J., Bourguignon-Igel, Valérie, Galvanin, A., Kotter, A., Helm, M. Lafontaine, D.L.J. , and Motorin, Y. (2018) “AlkAniline-Seq: profiling of m7G and m3C RNA modifications at single nucleotide resolution” Angewandte Chemie |DOI:10.1002/anie.201810946 Supplemental Data

63: Stamatopoulou, V., Parisot, P., De Vleeschouwer, C., Lafontaine, D.L.J. (2018) “Use of the iNo score to discriminate normal from altered nucleolar morphology, with applications in basic cell biology and potential in human disease diagnostics” Nature Protocols |DOI:10.1038/s41596-018-0044-3 Supplemental Data

62: Sharma, S., Hartmann, J.D., Watzinger, P., Klepper, A., Peifer, C., Koetter, P., Lafontaine, D.L.J., Entian, K.-D. (2018) “A single N1-methyladenosine on the large ribosomal subunit rRNA impacts locally its structure and the translation of key metabolic enzymes” Sci Rep 8: 11904 |DOI:10.1038/s41598-018-30383-z Supplemental Data

61: Jantsch, M. et al. (2018) “Positioning Europe for the EPITRANSCRIPTOMICS challenge” RNA Biol. |DOI:10.1080/15476286.2018.1460996

60: Pellegrino, S., Meyer, M., Zorbas, C., Boutcha, S.A., Saraf, K., Pelly, S.C., Yusupova, G., Evidente, A., Mathieu, V., Kornienko, A. Lafontaine, D.L.J., Yusupov, M. (2018) “The Amaryllidaceae alkaloid haemanthamine binds the eukaryotic ribosome to repress cancer cell growth” Structure 26: 1-10 |DOI:10.1016/j.str.2018.01.009 Supplemental Data

59: Vendramin, R., Verheyden, Y., Hideaki, I., Lucas, G., Nicolas, E., Saraf, K., Delli Ponti, R., Armaos, A., Izumikawa, K., Mestdagh, P. Lafontaine, D.L.J., Tartaglia, G. G., Takahashi, N., Marine, J.-C., Leucci, E. (2018) “SAMMSON fosters cancer cell fitness by enhancing concertedly mitochondrial and cytosolic translation” Nature Structural & Molecular Biology |DOI:10.1038/s41594-018-0143-4 Supplemental Data


58: Sharma, S., Marchand, V., Motorin, Y., Lafontaine, D.L.J. (2017) “Identification of sites of 2’-O-methylation vulnerability in human ribosomal RNAs by systematic mapping” Sci Rep 7: 11490 |DOI:10.1038/s41598-017-09734-9 Supplemental Data

57: Sharma, S., Yang, J., van Nues, R., Watzinger, P., Kötter, P., Lafontaine, D.L.J., Granneman, S., Entian, K.-D. (2017) “Specialized box C/D snoRNPs act as antisense guides to target RNA base acetylation” PLoS Genetics |DOI:10.1371/journal.pgen.1006804 Supplemental Data


56: Nicolas, E., Parisot, P., Pinto-Monteiro, C., de Walque, R., De Vleeschouwer, C., Lafontaine, D.L.J. (2016) “Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress” Nature Communications |DOI:10.1038/ncomms11390 Supplemental Data

55: Langhendries, J.-L., Nicolas, E., Doumont, G., Goldman, S., Lafontaine, D.L.J. (2016) “The human box C/D snoRNAs U3 and U8 are required for pre-rRNA processing and tumorigenesis” Oncotarget |DOI:10.18632/Oncotarget.11148

54: Bar, D.Z., Charar, C., Dorfman, J., Yadid, T., Tafforeau, L., Lafontaine, D.L.J., Gruenbaum, Y. (2016) “Cell size and fat content of dietary restricted Caenorhabditis elegans are regulated by ATX-2, a novel mTOR repressor” PNAS U.S.A. |DOI:10.1073/pnas.1512156113

53: Leucci, E., Vendramin, R., Spinazzi, M., Laurette, P., Fiers, M., Wouters, J., Radaelli, E., Eyckerman, S., Leonelli,C., Vanderheyden,K., Rogiers,A., Hermans, E., Baatsen, P., Aerts, S., Amant, F., Van Aelst, S., van den Oord, J., de Strooper, B., Davidson, I., Lafontaine, D.L.J., Gevaert, K., Vandesompele, J., Mestdagh, P., Marine, J.-C. (2016) “Melanoma addiction to the long non-coding RNA SAMMSON” Nature 531: 518-522

52: Sobecki, M., Mrouj, K., Camasses, A., Parisis, N., Nicolas, E., Lleres, D., Gerbe, F., Prieto, S., Krasinska, L., David, A., Eguren, M., Birling, M.-C., Urbach, S., Hem, S., Déjardin, J., Malumbres, M., Jay, P., Dulic, V., Lafontaine, D.L.J., Feil, R., Fisher, D. “The cell proliferation antigen Ki-67 organises heterochromatin” Elife 2016 Mar 7;5. pii: e13722. |DOI:10.7554/eLife.13722.

51: Sloan, K.E., Warda, A.S., Sharma, S., Entian, K.-D., Lafontaine, D.L.J., Bohnsack, M. (2016) “Tuning the ribosome: the influence of rRNA modification on eukaryotic ribosome biogenesis and function” RNA Biology |DOI:10.1080/15476286.2016.1259781

50: Meyer, B., Wurm, J.P., Sharma, S., Immer, C., Pogoryelov, D., Kötter, P., Lafontaine, D.L.J., Wöhnert, J., Entian, K.-D. (2016) “Ribosome biogenesis factor Tsr3 is the aminocarboxypropyltransferase responsible for 18S rRNA hypermodification in yeast and humans” Nucleic Acids Research |DOI: 10.1093/nar/gkw244


49: Sharma, S., Lafontaine, D.L.J. “View From A Bridge: A New Perspective on Eukaryotic rRNA Base Modification” Trends in Biochemical Sciences Oct. 2015

48: Hauenschild, R., Tserovski, L., Schmid, K., Thüring, K., Winz, M.L., Sharma, S., Entian K.-D., Wacheul, L., Lafontaine, D.L.J., Anderson, J., Alfonzo, J., Hildebrandt, A., Jäschke, A., Motorin, Y., Helm, M. “The reverse transcription signature of N-1-methyladenosine in RNA-seq is sequence dependent” Nucleic Acids Res 2015. Sep 13. pii: gkv895. [Epub ahead of print]

47: Zorbas, C., Nicolas, E., Wacheul, L., Huvelle, E., Heurgué-Hamard, V., Lafontaine, D.L.J. (2015) “The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis.” Molecular Biology of the Cell 26: 2080-2095.

46: Lafontaine, D.L.J. (2015). “Non-coding RNAs in ribosome synthesis and function.” Nature Structural & Molecular Biology 21(1): 11-19. Special Focus on ncRNAs. Editorial

45: Sharma, S., Langhendries, J.-L., Watzinger, P., Kötter, P., Entian, K.-D., Lafontaine, D.L.J. (2015) “Yeast Kre33 and Human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1”. Nucleic Acids Res doi: 10.1093/nar/gkv075


44: Létoquart, J., Huvelle, E., Wacheul, L., Bourgeois, G., Zorbas, C., Graille, M., Heurgué-Hamard, V., Lafontaine, D.L.J. (2014). “Structural and functional studies of Bud23-Trm112 reveal 18S rRNA N7-G1575 methylation occurs on late 40S precursor ribosomes.” PNAS U.S.A. Dec 23;111(51):E5518-26. doi: 10.1073/pnas.1413089111. Epub 2014 Dec 8.

43: Stanicki, D., Boutry, S., Laurent, S., Wacheul, L., Nicolas, E., Crombez, D., Vander Elst, L., Lafontaine, D.L.J. and Muller, R. N. (2014). “Carboxy-silane coated iron oxide nanoparticles: a convenient platform for cellular and small animal imaging.” J Mater Chem B 2: 387-397. Last two authors are corresponding authors.

42: Ban, N., Beckmann, R., Cate, J. H., Dinman, J. D., Dragon, F., Ellis, S. R., Lafontaine, D.L.J., Lindahl, L., Liljas, A., Lipton, J. M., McAlear, M. A., Moore, P. B., Noller, H. F., Ortega, J., Panse, V. G., Ramakrishnan, V., Spahn, C. M., Steitz, T. A., Tchorzewski, M., Tollervey, D., Warren, A. J., Williamson, J. R., Wilson, D., Yonath, A. and Yusupov, M. (2014). “A new system for naming ribosomal proteins.” Curr Opin Struct Biol 24: 165-169.


41: Tafforeau, L., Zorbas, C., Langhendries, J. L., Mullineux, S. T., Stamatopoulou, V., Mullier, R., Wacheul, L. and Lafontaine, D.L.J. (2013). “The complexity of human ribosome biogenesis revealed by systematic nucleolar screening of Pre-rRNA processing factors.” Molecular Cell 51: 539-551. |DOI: 10.1016/j.molcel.2013.08.011 Supplemental Data


40: Schillewaert, S., Wacheul, L., Lhomme, F. and Lafontaine, D.L.J. (2012). “The evolutionarily conserved protein Las1 is required for pre-rRNA processing at both ends of ITS2.” Mol Cell Biol 32: 430-444.

39: Figaro, S., Wacheul, L., Schillewaert, S., Graille, M., Huvelle, E., Mongeard, R., Zorbas, C., Lafontaine, D.L.J. and Heurgue-Hamard, V. (2012). “Trm112 is required for Bud23-mediated methylation of the 18S rRNA at position G1575.” Mol Cell Biol 32: 2254-2267. Equal contribution of last two authors.

38: Mullineux, S. T. and Lafontaine, D. L. J. (2012). “Mapping the cleavage sites on mammalian pre-rRNAs: where do we stand?” Biochimie 94: 1521-1532.

37: Serviene, E., Luksa, J., Orentaite, I., Lafontaine, D.L.J. and Urbonavicius, J. (2012). “Screening the budding yeast genome reveals unique factors affecting K2 toxin susceptibility.” PLoS One 7: e50779. Equal contribution of last two authors.


36: Lamaye, F., Galliot, S., Alibardi, L., Lafontaine, D.L.J. and Thiry, M. (2011). “Nucleolar structure across evolution: the transition between bi- and tri-compartmentalized nucleoli lies within the class Reptilia.” J Struct Biol 174: 352-359.

35: Thiry, M., Lamaye, F. and Lafontaine, D.L.J. (2011). “The nucleolus: when 2 became 3.” Nucleus 2: 289-293.

34: Leporé, N. and Lafontaine, D.L.J. (2011). “A functional interface at the rDNA connects rRNA synthesis, pre-rRNA processing and nucleolar surveillance in budding yeast.” PLoS One 6: e24962.


33: Lafontaine, D.L.J. (2010). “A ‘garbage can’ for ribosomes: how eukaryotes degrade their ribosomes.” Trends Biochem Sci 35: 267-277.

32: Hernandez-Verdun, D., Roussel, P., Thiry, M., Sirri, V. and Lafontaine, D.L.J. (2010). “The nucleolus: structure/function relationship in RNA metabolism.” Wiley Interdiscip Rev RNA 1: 415-431.

31: Leporé, N. and Lafontaine, D.L.J. (2010). “[<< Catch me if you can >>: how the structural and functional integrity of eukaryotic RNA molecules is monitored by surveillance mechanisms].” Med Sci (Paris) 26: 259-266.


30: Wery, M., Ruidant, S., Schillewaert, S., Lepore, N. and Lafontaine, D.L.J. (2009). “The nuclear poly(A) polymerase and Exosome cofactor Trf5 is recruited cotranscriptionally to nucleolar surveillance.” RNA 15: 406-419.


29: Vanrobays, E., Leplus, A., Osheim, Y. N., Beyer, A. L., Wacheul, L. and Lafontaine, D.L.J. (2008). “TOR regulates the subcellular distribution of DIM2, a KH domain protein required for cotranscriptional ribosome assembly and pre-40S ribosome export.” RNA 14: 2061-2073.

28: Qiu, H., Eifert, J., Wacheul, L., Thiry, M., Berger, A. C., Jakovljevic, J., Woolford, J. L., Jr., Corbett, A. H., Lafontaine, D.L.J., Terns, R. M. and Terns, M. P. (2008). “Identification of genes that function in the biogenesis and localization of small nucleolar RNAs in Saccharomyces cerevisiae.” Mol Cell Biol 28: 3686-3699.


27: Chedin, S., Laferte, A., Hoang, T., Lafontaine, D.L.J., Riva, M. and Carles, C. (2007). “Is ribosome synthesis controlled by pol I transcription?” Cell Cycle 6: 11-15.


26: Thiry, M. and Lafontaine, D.L.J. (2005). “Birth of a nucleolus: the evolution of nucleolar compartments.” Trends Cell Biol 15: 194-199.

25: Hoang, T., Peng, W. T., Vanrobays, E., Krogan, N., Hiley, S., Beyer, A. L., Osheim, Y. N., Greenblatt, J., Hughes, T. R. and Lafontaine, D.L.J. (2005). “Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction.” Mol Cell Biol 25: 5523-5534.


24: Vanrobays, E., Gelugne, J. P., Caizergues-Ferrer, M. and Lafontaine, D.L.J. (2004). “Dim2p, a KH-domain protein required for small ribosomal subunit synthesis.” RNA 10: 645-656.

23: Lafontaine, D.L.J. (2004). Eukaryotic ribosome synthesis. Protein Synthesis and Ribosome Structure. K. Nierhaus, Wiley-InterScience: 107-143.

22: Colau, G., Thiry, M., Leduc, V., Bordonne, R. and Lafontaine, D.L.J. (2004). “The small nucle(ol)ar RNA cap trimethyltransferase is required for ribosome synthesis and intact nucleolar morphology.” Mol Cell Biol 24: 7976-7986.


21: Verheggen, C., Lafontaine, D.L.J., Samarsky, D., Mouaikel, J., Blanchard, J. M., Bordonne, R. and Bertrand, E. (2002). “Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments.” EMBO J 21: 2736-2745.


20: Lafontaine, D.L.J. and Tollervey, D. (2001). “The function and synthesis of ribosomes.” Nature Reviews Mol Cell Biol 2: 514-520.

19: Verheggen, C., Mouaikel, J., Thiry, M., Blanchard, J. M., Tollervey, D., Bordonne, R., Lafontaine, D.L.J. and Bertrand, E. (2001). “Box C/D small nucleolar RNA trafficking involves small nucleolar RNP proteins, nucleolar factors and a novel nuclear domain.” EMBO J 20: 5480-5490. Equal contribution of last two authors.

18: Senger, B., Lafontaine, D.L.J., Graindorge, J. S., Gadal, O., Camasses, A., Sanni, A., Garnier, J. M., Breitenbach, M., Hurt, E. and Fasiolo, F. (2001). “The nucle(ol)ar Tif6p and Efl1p are required for a late cytoplasmic step of ribosome synthesis.” Molecular Cell 8: 1363-1373.

17: Lafontaine, D.L.J. and Tollervey, D. (2001). Ribosomal RNA. Encyclopedia of Life Sciences (, MacMillan – Nature

16: Dez, C., Henras, A., Faucon, B., Lafontaine, D.L.J., Caizergues-Ferrer, M. and Henry, Y. (2001). “Stable expression in yeast of the mature form of human telomerase RNA depends on its association with the box H/ACA small nucleolar RNP proteins Cbf5p, Nhp2p and Nop10p.” Nucleic Acids Res 29: 598-603.


15: Lafontaine, D.L.J. and Tollervey, D. (2000). “Synthesis and assembly of the box C+D small nucleolar RNPs.” Mol Cell Biol 20: 2650-2659.

14: Kufel, J., Allmang, C., Chanfreau, G., Petfalski, E., Lafontaine, D. L. J. and Tollervey, D. (2000). “Precursors to the U3 small nucleolar RNA lack small nucleolar RNP proteins but are stabilized by La binding.” Mol Cell Biol 20: 5415-5424.

13: Colley, A., Beggs, J. D., Tollervey, D. and Lafontaine, D.L.J. (2000). “Dhr1p, a putative DEAH-box RNA helicase, is associated with the box C+D snoRNP U3.” Mol Cell Biol 20: 7238-7246.


12: Massenet, S., Motorin, Y., Lafontaine, D.L.J., Hurt, E. C., Grosjean, H. and Branlant, C. (1999). “Pseudouridine mapping in the Saccharomyces cerevisiae spliceosomal U small nuclear RNAs (snRNAs) reveals that pseudouridine synthase pus1p exhibits a dual substrate specificity for U2 snRNA and tRNA.” Mol Cell Biol 19: 2142-2154.

11: Lafontaine, D.L.J. and Tollervey, D. (1999). “Nop58p is a common component of the box C+D snoRNPs that is required for snoRNA stability.” RNA 5: 455-467.

10: Fortes, P., Kufel, J., Fornerod, M., Polycarpou-Schwarz, M., Lafontaine, D.L.J., Tollervey, D. and Mattaj, I. W. (1999). “Genetic and physical interactions involving the yeast nuclear cap-binding complex.” Mol Cell Biol 19: 6543-6553.


9: Lafontaine, D.L.J., Bousquet-Antonelli, C., Henry, Y., Caizergues-Ferrer, M. and Tollervey, D. (1998). “The box H + ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase.” Genes and Development 12: 527-537.

8: Lafontaine, D.L.J. and Tollervey, D. (1998). “Birth of the snoRNPs: the evolution of the modification-guide snoRNAs.” Trends Biochem Sci 23: 383-388.

7: Lafontaine, D.L.J., Preiss, T. and Tollervey, D. (1998). “Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis?” Mol Cell Biol 18: 2360-2370.

6: Lafontaine, D.L.J. and Tollervey, D. (1998). Regulatory aspects of rRNA modifications and pre-rRNA processing. Modification and editing of RNA. H. Grosjean and R. Benne. Washington, ASM Press: 281-288.


5: Housen, I., Demonte, D., Lafontaine, D.L.J. and Vandenhaute, J. (1997). “Cloning and characterization of the KlDIM1 gene from Kluyveromyces lactis encoding the m2(6)A dimethylase of the 18S rRNA.” Yeast 13: 777-781.


4: Lafontaine, D.L.J. and Tollervey, D. (1996). “One-step PCR mediated strategy for the construction of conditionally expressed and epitope tagged yeast proteins.” Nucleic Acids Res 24: 3469-3471.


3: Lafontaine, D.L.J., Vandenhaute, J. and Tollervey, D. (1995). “The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast.” Genes and Development 9: 2470-2481.

2: Lafontaine, D.L.J. and Tollervey, D. (1995). “Trans-acting factors in yeast pre-rRNA and pre-snoRNA processing.” Biochem Cell Biol 73: 803-812.


1: Lafontaine, D.L.J., Delcour, J., Glasser, A. L., Desgres, J. and Vandenhaute, J. (1994). “The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3′-terminal loop of 18 S rRNA is essential in yeast.” J Mol Biol 241: 492-497.

Comments are closed.