Molecular, Cellular & Pathophysiological Aspects of Ribosome Biogenesis

Ribosomes are essential cellular nanomachines, converting the genetic information encoded in messenger RNAs (mRNAs) into proteins playing structural or catalytic roles in the cell. The human ribosome contains four rRNAs and eighty ribosomal proteins ...

Understanding Human Ribosome Biogenesis

We are characterizing ribosome assembly pathways in human cells and budding yeast. We are particularly interested by RNA processing and RNA modification. Eukaryotic ribosome biogenesis is a complex process, which is initiated in the nucleolus, proceeds into the nucleoplasm and is finalized in the cytoplasm. All three RNA polymerases are ...

Understanding Human Nucleolar Structure

We are characterizing the principles of nucleolar structure integrity maintenance and dynamics. Ribosome synthesis is initiated in the nucleolus...

Pathophysiological Aspects of Ribosome Biogenesis

We are developing novel nucleolar cancer biomarkers for improved classification of malignancies and patient stratification. We are implementing animal models to study the effects of ribosome...

Structural Approach to Ribosome Biogenesis

In collaboration with structural biologists, we are characterizing the 3-D structure of assembly factors involved in ribosome biogenesis.

Glutamine & Nucleolar surveillance

Glutamine & Nucleolar surveillance
Nucleolar surveillance is a p53-dependent anti-tumoral pathway activated upon ribosome biogenesis dysfunction. It had remained unclear why liquid tumours respond better to ribosome biogenesis inhibitors...

EMBO RIBOSOME 2022, August 17-21, Engelberg

EMBO RIBOSOME 2022, August 17-21, Engelberg
Co-organizers: Ute Kothe, Dieter Kressler, Denis Lafontaine, Tom Meier, Vikam Panse To Register, please visit the official EMBO website

Dihydrouridine on messenger RNAs slows ribosomes!

Dihydrouridine on messenger RNAs slows ribosomes!
On the cover: In this issue of Molecular Cell, Finet et al. (pp. 404–419) use a transcriptome-wide approach to reveal that the dihydrouridine RNA modification (the...

Fibrillarin is required for Neural Crest Cell maturation

Fibrillarin is required for Neural Crest Cell maturation
Ribosomes are essential nanomachines responsible for protein production in all cells. Ribosomopathies are diseases caused by improper ribosome formation due to mutations in ribosomal proteins...

The Nucleolus as a Multiphase Liquid Condensate

The Nucleolus as a Multiphase Liquid Condensate
The nucleolus is the most prominent nuclear body and serves a fundamentally important biological role as a site of ribonucleoprotein particle assembly, primarily dedicated to...

The “iNo score”: Towards bringing the nucleolus in the clinics

The “iNo score”: Towards bringing the nucleolus in the clinics
Using the iNo score to discriminate normal from altered nucleolar morphology, with applications in basic cell biology and potential in human disease diagnostics     ...

The 11th International Ribosome Synthesis Meeting, Magog, Canada, August 1-5, 2018

The 11th International Ribosome Synthesis Meeting, Magog, Canada, August 1-5, 2018
The 11th International Ribosome Synthesis meeting will take place in Magog, Mont Orford, near Montreal, Canada form the 1-5 August 2018 at Manoir des Sables....

Curing cancer with Daffodils?

Curing cancer with Daffodils?
Pellegrino et al., have shown that haemanthamine inhibits both ribosome biogenesis and function, providing for the first time the molecular basis of the anticancer properties...