In an amazing collaboration with the Eva Maria Novoa Lab (CRG, Barcelona, Spain), … Milenkovic et al. demonstrate that rRNA modifications are differentially modified across tissues, developmental stages, and in disease. The authors show that rRNA modification patterns, also termed “epitranscriptomic rRNA fingerprints” are sufficient to accurately identify tissue of…
Thank you to the organizers for their invitation as Session Chair Video recording of “RNA Modification” Session Introduction: with friends Tom Meier (Albert Einstein College of Medicine, New York, U.S.A.) and Yi-Tao Yu (U Rochester, U.S.A.)
Co-organizers: Ute Kothe, Dieter Kressler, Denis Lafontaine, Tom Meier, Vikam Panse To Register, please visit the official EMBO website
Ribosomes are essential nanomachines responsible for protein production in all cells. Ribosomopathies are diseases caused by improper ribosome formation due to mutations in ribosomal proteins or ribosome assembly factors. Such diseases primarily affect the brain and blood, and it is unclear how malfunctioning of a process as general as ribosome…
Using the iNo score to discriminate normal from altered nucleolar morphology, with applications in basic cell biology and potential in human disease diagnostics Ribosome biogenesis is initiated in the nucleolus, a cell condensate essential to gene expression, whose morphology informs cancer pathologists on the health…