XMolecular, Cellular & Pathophysiological Aspects of Ribosome Biogenesis

Ribosomes are essential cellular nanomachines, converting the genetic information encoded in messenger RNAs (mRNAs) into proteins playing structural or catalytic roles in the cell. The human ribosome contains four rRNAs and eighty ribosomal proteins ...

X Understanding Human Ribosome Biogenesis

We are characterizing ribosome assembly pathways in human cells and budding yeast. We are particularly interested by RNA processing and RNA modification. Eukaryotic ribosome biogenesis is a complex process, which is initiated in the nucleolus, proceeds into the nucleoplasm and is finalized in the cytoplasm. All three RNA polymerases are ...

XUnderstanding Human Nucleolar Structure

We are characterizing the principles of nucleolar structure integrity maintenance and dynamics. Ribosome synthesis is initiated in the nucleolus...

XPathophysiological Aspects of Ribosome Biogenesis

We are developing novel nucleolar cancer biomarkers for improved classification of malignancies and patient stratification. We are implementing animal models to study the effects of ribosome...

XStructural Approach to Ribosome Biogenesis

In collaboration with structural biologists, we are characterizing the 3-D structure of assembly factors involved in ribosome biogenesis.

Involvement of U3 and U8 box C/D snoRNAs in tumorigenesis

Small nucleolar RNAs (snoRNAs) are emerging as a novel class of proto-oncogenes and tumor suppressors; their involvement in tumorigenesis remains unclear. The box C/D snoRNAs U3 and ...

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