- Sharma, S., Hartmann, J.D., Watzinger, P., Klepper, A., Peifer, C., Koetter, P., Lafontaine, D.L.J., Entian, K.-D. (2018) “A single N1-methyladenosine on the large ribosomal subunit rRNA impacts locally its structure and the translation of key metabolic enzymes” bioRXiv | DOI:

- Jantsch, M. et al. (2018) “Positioning Europe for the EPITRANSCRIPTOMICS challenge” RNA Biol. | DOI:

- Pellegrino, S., Meyer, M., Zorbas, C., Boutcha, S.A., Saraf, K., Pelly, S.C., Yusupova, G., Evidente, A., Mathieu, V., Kornienko, A. Lafontaine, D.L.J., Yusupov, M. (2018) “The Amaryllidaceae alkaloid haemanthamine binds the eukaryotic ribosome to repress cancer cell growth” Structure 26: 1-10 | DOI:10.1016/j.str.2018.01.009


- Sharma, S., Marchand, V., Motorin, Y., Lafontaine, D.L.J. (2017) “Identification of sites of 2’-O-methylation vulnerability in human ribosomal RNAs by systematic mapping” Sci Rep 7: 11490 | DOI:10.1038/s41598-017-09734-9

- Sharma, S., Yang, J., van Nues, R., Watzinger, P., Kötter, P., Lafontaine, D.L.J., Granneman, S., Entian, K.-D. (2017) “Specialized box C/D snoRNPs act as antisense guides to target RNA base acetylation” PLoS Genetics DOI: 10.1371/journal.pgen.1006804


- Nicolas, E., Parisot, P., Pinto-Monteiro, C., de Walque, R., De Vleeschouwer, C., Lafontaine, D.L.J. (2016) “Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress” Nature Communications doi: 10.1038/ncomms11390

- Langhendries, J.-L., Nicolas, E., Doumont, G., Goldman, S., Lafontaine, D.L.J. (2016) “The human box C/D snoRNAs U3 and U8 are required for pre-rRNA processing and tumorigenesis” Oncotarget doi: 10.18632/Oncotarget.11148

- Bar, D.Z., Charar, C., Dorfman, J., Yadid, T., Tafforeau, L., Lafontaine, D.L.J., Gruenbaum, Y. (2016) “Cell size and fat content of dietary restricted Caenorhabditis elegans are regulated by ATX-2, a novel mTOR repressor” PNAS U.S.A. doi: 10.1073/pnas.1512156113

- Leucci, E., Vendramin, R., Spinazzi, M., Laurette, P., Fiers, M., Wouters, J., Radaelli, E., Eyckerman, S., Leonelli,C., Vanderheyden,K., Rogiers,A., Hermans, E., Baatsen, P., Aerts, S., Amant, F., Van Aelst, S., van den Oord, J., de Strooper, B., Davidson, I., Lafontaine, D.L.J., Gevaert, K., Vandesompele, J., Mestdagh, P., Marine, J.-C. (2016) “Melanoma addiction to the long non-coding RNA SAMMSON” Nature 531: 518-522

- Sobecki, M., Mrouj, K., Camasses, A., Parisis, N., Nicolas, E., Lleres, D., Gerbe, F., Prieto, S., Krasinska, L., David, A., Eguren, M., Birling, M.-C., Urbach, S., Hem, S., Déjardin, J., Malumbres, M., Jay, P., Dulic, V., Lafontaine, D.L.J., Feil, R., Fisher, D. “The cell proliferation antigen Ki-67 organises heterochromatin” Elife 2016 Mar 7;5. pii: e13722. doi: 10.7554/eLife.13722.

- Sloan, K.E., Warda, A.S., Sharma, S., Entian, K.-D., Lafontaine, D.L.J., Bohnsack, M. (2016) “Tuning the ribosome: the influence of rRNA modification on eukaryotic ribosome biogenesis and function” RNA Biology doi: 10.1080/15476286.2016.1259781

- Meyer, B., Wurm, J.P., Sharma, S., Immer, C., Pogoryelov, D., Kötter, P., Lafontaine, D.L.J., Wöhnert, J., Entian, K.-D. (2016) “Ribosome biogenesis factor Tsr3 is the aminocarboxypropyltransferase responsible for 18S rRNA hypermodification in yeast and humans” Nucleic Acids Research doi: 10.1093/nar/gkw244


- Sharma, S., Lafontaine, D.L.J. “View From A Bridge: A New Perspective on Eukaryotic rRNA Base Modification” Trends in Biochemical Sciences Oct. 2015

- Hauenschild, R., Tserovski, L., Schmid, K., Thüring, K., Winz, M.L., Sharma, S., Entian K.-D., Wacheul, L., Lafontaine, D.L.J., Anderson, J., Alfonzo, J., Hildebrandt, A., Jäschke, A., Motorin, Y., Helm, M. “The reverse transcription signature of N-1-methyladenosine in RNA-seq is sequence dependent” Nucleic Acids Res 2015. Sep 13. pii: gkv895. [Epub ahead of print]

-Zorbas, C., Nicolas, E., Wacheul, L., Huvelle, E., Heurgué-Hamard, V., Lafontaine, D.L.J. (2015) “The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis.” Molecular Biology of the Cell 26: 2080-2095.

-Lafontaine, D.L.J. (2015). “Non-coding RNAs in ribosome synthesis and function.” Nature Structural & Molecular Biology 21(1): 11-19. Special Focus on ncRNAs.

-Sharma, S., Langhendries, J.-L., Watzinger, P., Kötter, P., Entian, K.-D., Lafontaine, D.L.J. (2015) “Yeast Kre33 and Human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1″. Nucleic Acids Res doi: 10.1093/nar/gkv075


-Létoquart, J., Huvelle, E., Wacheul, L., Bourgeois, G., Zorbas, C., Graille, M., Heurgué-Hamard, V., Lafontaine, D.L.J. (2014). “Structural and functional studies of Bud23-Trm112 reveal 18S rRNA N7-G1575 methylation occurs on late 40S precursor ribosomes.” Proc Natl Acad Sci U.S.A. Dec 23;111(51):E5518-26. doi: 10.1073/pnas.1413089111. Epub 2014 Dec 8.

-Stanicki, D., Boutry, S., Laurent, S., Wacheul, L., Nicolas, E., Crombez, D., Vander Elst, L., Lafontaine, D.L.J. and Muller, R. N. (2014). “Carboxy-silane coated iron oxide nanoparticles: a convenient platform for cellular and small animal imaging.” J Mater Chem B 2: 387-397. Last two authors are corresponding authors.

-Ban, N., Beckmann, R., Cate, J. H., Dinman, J. D., Dragon, F., Ellis, S. R., Lafontaine, D.L.J., Lindahl, L., Liljas, A., Lipton, J. M., McAlear, M. A., Moore, P. B., Noller, H. F., Ortega, J., Panse, V. G., Ramakrishnan, V., Spahn, C. M., Steitz, T. A., Tchorzewski, M., Tollervey, D., Warren, A. J., Williamson, J. R., Wilson, D., Yonath, A. and Yusupov, M. (2014). “A new system for naming ribosomal proteins.” Curr Opin Struct Biol 24: 165-169.


-Tafforeau, L., Zorbas, C., Langhendries, J. L., Mullineux, S. T., Stamatopoulou, V., Mullier, R., Wacheul, L. and Lafontaine, D.L.J. (2013). “The complexity of human ribosome biogenesis revealed by systematic nucleolar screening of Pre-rRNA processing factors.” Molecular Cell 51: 539-551.


-Schillewaert, S., Wacheul, L., Lhomme, F. and Lafontaine, D.L.J. (2012). “The evolutionarily conserved protein Las1 is required for pre-rRNA processing at both ends of ITS2.” Mol Cell Biol 32: 430-444.

-Figaro, S., Wacheul, L., Schillewaert, S., Graille, M., Huvelle, E., Mongeard, R., Zorbas, C., Lafontaine, D.L.J. and Heurgue-Hamard, V. (2012). “Trm112 is required for Bud23-mediated methylation of the 18S rRNA at position G1575.” Mol Cell Biol 32: 2254-2267. Equal contribution of last two authors.

-Mullineux, S. T. and Lafontaine, D. L. J. (2012). “Mapping the cleavage sites on mammalian pre-rRNAs: where do we stand?” Biochimie 94: 1521-1532.

-Serviene, E., Luksa, J., Orentaite, I., Lafontaine, D.L.J. and Urbonavicius, J. (2012). “Screening the budding yeast genome reveals unique factors affecting K2 toxin susceptibility.” PLoS One 7: e50779. Equal contribution of last two authors.


-Lamaye, F., Galliot, S., Alibardi, L., Lafontaine, D.L.J. and Thiry, M. (2011). “Nucleolar structure across evolution: the transition between bi- and tri-compartmentalized nucleoli lies within the class Reptilia.” J Struct Biol 174: 352-359.

-Thiry, M., Lamaye, F. and Lafontaine, D.L.J. (2011). “The nucleolus: when 2 became 3.” Nucleus 2: 289-293.

-Leporé, N. and Lafontaine, D.L.J. (2011). “A functional interface at the rDNA connects rRNA synthesis, pre-rRNA processing and nucleolar surveillance in budding yeast.” PLoS One 6: e24962.


-Lafontaine, D.L.J. (2010). “A ‘garbage can’ for ribosomes: how eukaryotes degrade their ribosomes.” Trends Biochem Sci 35: 267-277.

-Hernandez-Verdun, D., Roussel, P., Thiry, M., Sirri, V. and Lafontaine, D.L.J. (2010). “The nucleolus: structure/function relationship in RNA metabolism.” Wiley Interdiscip Rev RNA 1: 415-431.

-Leporé, N. and Lafontaine, D.L.J. (2010). “[<< Catch me if you can >>: how the structural and functional integrity of eukaryotic RNA molecules is monitored by surveillance mechanisms].” Med Sci (Paris) 26: 259-266.


-Wery, M., Ruidant, S., Schillewaert, S., Lepore, N. and Lafontaine, D.L.J. (2009). “The nuclear poly(A) polymerase and Exosome cofactor Trf5 is recruited cotranscriptionally to nucleolar surveillance.” RNA 15: 406-419.


-Vanrobays, E., Leplus, A., Osheim, Y. N., Beyer, A. L., Wacheul, L. and Lafontaine, D.L.J. (2008). “TOR regulates the subcellular distribution of DIM2, a KH domain protein required for cotranscriptional ribosome assembly and pre-40S ribosome export.” RNA 14: 2061-2073.

-Qiu, H., Eifert, J., Wacheul, L., Thiry, M., Berger, A. C., Jakovljevic, J., Woolford, J. L., Jr., Corbett, A. H., Lafontaine, D.L.J., Terns, R. M. and Terns, M. P. (2008). “Identification of genes that function in the biogenesis and localization of small nucleolar RNAs in Saccharomyces cerevisiae.” Mol Cell Biol 28: 3686-3699.


-Chedin, S., Laferte, A., Hoang, T., Lafontaine, D.L.J., Riva, M. and Carles, C. (2007). “Is ribosome synthesis controlled by pol I transcription?” Cell Cycle 6: 11-15.


-Thiry, M. and Lafontaine, D.L.J. (2005). “Birth of a nucleolus: the evolution of nucleolar compartments.” Trends Cell Biol 15: 194-199.

-Hoang, T., Peng, W. T., Vanrobays, E., Krogan, N., Hiley, S., Beyer, A. L., Osheim, Y. N., Greenblatt, J., Hughes, T. R. and Lafontaine, D.L.J. (2005). “Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction.” Mol Cell Biol 25: 5523-5534.


-Vanrobays, E., Gelugne, J. P., Caizergues-Ferrer, M. and Lafontaine, D.L.J. (2004). “Dim2p, a KH-domain protein required for small ribosomal subunit synthesis.” RNA 10: 645-656.

-Lafontaine, D.L.J. (2004). Eukaryotic ribosome synthesis. Protein Synthesis and Ribosome Structure. K. Nierhaus, Wiley-InterScience: 107-143.

-Colau, G., Thiry, M., Leduc, V., Bordonne, R. and Lafontaine, D.L.J. (2004). “The small nucle(ol)ar RNA cap trimethyltransferase is required for ribosome synthesis and intact nucleolar morphology.” Mol Cell Biol 24: 7976-7986.


-Verheggen, C., Lafontaine, D.L.J., Samarsky, D., Mouaikel, J., Blanchard, J. M., Bordonne, R. and Bertrand, E. (2002). “Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments.” EMBO J 21: 2736-2745.


-Lafontaine, D.L.J. and Tollervey, D. (2001). “The function and synthesis of ribosomes.” Nature Reviews Mol Cell Biol 2: 514-520.

-Verheggen, C., Mouaikel, J., Thiry, M., Blanchard, J. M., Tollervey, D., Bordonne, R., Lafontaine, D.L.J. and Bertrand, E. (2001). “Box C/D small nucleolar RNA trafficking involves small nucleolar RNP proteins, nucleolar factors and a novel nuclear domain.” EMBO J 20: 5480-5490. Equal contribution of last two authors.

-Senger, B., Lafontaine, D.L.J., Graindorge, J. S., Gadal, O., Camasses, A., Sanni, A., Garnier, J. M., Breitenbach, M., Hurt, E. and Fasiolo, F. (2001). “The nucle(ol)ar Tif6p and Efl1p are required for a late cytoplasmic step of ribosome synthesis.” Molecular Cell 8: 1363-1373.

-Lafontaine, D.L.J. and Tollervey, D. (2001). Ribosomal RNA. Encyclopedia of Life Sciences (, MacMillan – Nature

-Dez, C., Henras, A., Faucon, B., Lafontaine, D.L.J., Caizergues-Ferrer, M. and Henry, Y. (2001). “Stable expression in yeast of the mature form of human telomerase RNA depends on its association with the box H/ACA small nucleolar RNP proteins Cbf5p, Nhp2p and Nop10p.” Nucleic Acids Res 29: 598-603.


-Lafontaine, D.L.J. and Tollervey, D. (2000). “Synthesis and assembly of the box C+D small nucleolar RNPs.” Mol Cell Biol 20: 2650-2659.

-Kufel, J., Allmang, C., Chanfreau, G., Petfalski, E., Lafontaine, D. L. J. and Tollervey, D. (2000). “Precursors to the U3 small nucleolar RNA lack small nucleolar RNP proteins but are stabilized by La binding.” Mol Cell Biol 20: 5415-5424.

-Colley, A., Beggs, J. D., Tollervey, D. and Lafontaine, D.L.J. (2000). “Dhr1p, a putative DEAH-box RNA helicase, is associated with the box C+D snoRNP U3.” Mol Cell Biol 20: 7238-7246.


-Massenet, S., Motorin, Y., Lafontaine, D.L.J., Hurt, E. C., Grosjean, H. and Branlant, C. (1999). “Pseudouridine mapping in the Saccharomyces cerevisiae spliceosomal U small nuclear RNAs (snRNAs) reveals that pseudouridine synthase pus1p exhibits a dual substrate specificity for U2 snRNA and tRNA.” Mol Cell Biol 19: 2142-2154.

-Lafontaine, D.L.J. and Tollervey, D. (1999). “Nop58p is a common component of the box C+D snoRNPs that is required for snoRNA stability.” RNA 5: 455-467.

-Fortes, P., Kufel, J., Fornerod, M., Polycarpou-Schwarz, M., Lafontaine, D.L.J., Tollervey, D. and Mattaj, I. W. (1999). “Genetic and physical interactions involving the yeast nuclear cap-binding complex.” Mol Cell Biol 19: 6543-6553.


-Lafontaine, D.L.J., Bousquet-Antonelli, C., Henry, Y., Caizergues-Ferrer, M. and Tollervey, D. (1998). “The box H + ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase.” Genes Dev 12: 527-537.

-Lafontaine, D.L.J. and Tollervey, D. (1998). “Birth of the snoRNPs: the evolution of the modification-guide snoRNAs.” Trends Biochem Sci 23: 383-388.

-Lafontaine, D.L.J., Preiss, T. and Tollervey, D. (1998). “Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis?” Mol Cell Biol 18: 2360-2370.

-Lafontaine, D.L.J. and Tollervey, D. (1998). Regulatory aspects of rRNA modifications and pre-rRNA processing. Modification and editing of RNA. H. Grosjean and R. Benne. Washington, ASM Press: 281-288.


-Housen, I., Demonte, D., Lafontaine, D.L.J. and Vandenhaute, J. (1997). “Cloning and characterization of the KlDIM1 gene from Kluyveromyces lactis encoding the m2(6)A dimethylase of the 18S rRNA.” Yeast 13: 777-781.


-Lafontaine, D.L.J. and Tollervey, D. (1996). “One-step PCR mediated strategy for the construction of conditionally expressed and epitope tagged yeast proteins.” Nucleic Acids Res 24: 3469-3471.


-Lafontaine, D.L.J., Vandenhaute, J. and Tollervey, D. (1995). “The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast.” Genes Dev 9: 2470-2481.

-Lafontaine, D.L.J. and Tollervey, D. (1995). “Trans-acting factors in yeast pre-rRNA and pre-snoRNA processing.” Biochem Cell Biol 73: 803-812.


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